A great study conducted by Indiana University School of Medicine researchers found that a series of RNA biomarkers in blood that may help identify who is at risk for committing suicide.In Every year around one million people commit suicide.”Suicide is a big problem in psychiatry. It’s a big problem in the civilian realm, it’s a big problem in the military realm and there are no objective markers,” said Dr. Niculescu, director of the Laboratory of Neurophenomics at the Institute of Psychiatric Research at the IU School of Medicine.the researchers said the biomarkers were found at significantly higher levels in the blood of both bipolar disorder patients with thoughts of suicide as well in a group of people who had committed suicide.
People having suicidal thoughts never reveal when we ask to them.There is no effective way to stop them .Researchers hope that this new study will help in such cases.The lead researcher Alexander B. Niculescu III,and his team followed a large group of patients diagnosed with bipolar disorder,over a period of three year by completing interviews and taking blood samples every three to six months.The researchers conducted a variety of analyses of the blood of a subset of participants who reported a dramatic shift from no suicidal thoughts to strong suicidal ideation. They identified differences in gene expression between the “low” and “high” states of suicidal thoughts and subjected those findings to a system of genetic and genomic analysis called Convergent .The researchers found that the marker SAT1 and a series of other markers provided the strongest biological “signal” associated with suicidal thoughts.
Researchers analyzed blood samples from suicide victims and found that some of same top markers were significantly elevated.Finally, the researchers analyzed blood test results from two additional groups of patients and found that high blood levels of the biomarkers were correlated with future suicide-related hospitalizations, as well as hospitalizations that had occurred before the blood tests.But the major limitation in this research is subjects were all male,According to the researchers there could be gender differences,more extensive studies needed for further explanations