A team of New York Stem Cell Foundation (NYSCF) Research Institute scientists create human born from skin cells.This generation of patient-specific bone substitutes from skin cells will help patients having large born defects and they may elicit immune rejection or other types of complexity during the treatment of large born defects and critical injuries .
This great findings will facilitate the development of customizable, three-dimensional bone grafts on-demand, matched to fit the exact needs and immune profile of a patient. Taking skin cells, the NYSCF scientists utilized an advanced technique called “reprogramming” to revert adult cells into an embryonic-like state. These induced pluripotent stem (iPS) cells carry the same genetic information as the patient and they can become any of the body’s cell types
Bone defects and injuries are currently treated with bone grafts, taken either from another part of the patient’s body or a donor bone bank, or with synthetic substitutes.but None of these permit complex reconstruction,and may faces immune rejection or fail to integrate with surrounding connective tissues
The scientists caution that although these results represent a major advance, further research is necessary before skin cell-derived bone grafts reach patients. Next steps include protocol optimization and the successful growth of blood vessels within the bone.
“Following from these findings, we will be able to create tailored bone grafts, on demand, for patients without any immune rejection issues,” said Susan L. Solomon, CEO of NYSCF. “This is not a good approach, it is the best approach to repair devastating damage or defects.”she said.